LIST OF TEN SIGNIFICANT EVENTS DURING FETAL DEVELOPMENT

1. Day 2 – Fertilization. This is significant because without this, there would be no baby.

Fertilization:


www.nrlc.org/abortion/facts/fetaldevelopment.html

2. 4th week - heart is beating. For many centuries, the beating heart was used to establish whether or not someone was alive. To this day, we still assess that for one of the signs of life.

3. 1 ½ months – brain waves can be measured with EEG. Heart chambers and valves are formed. I thought this was significant because it meant heart and mind are beginning to function. Sort of analogous to the makeup of all that is human, thinking and feeling beings. I did not know I was investigating an area of debate between various groups on the topic of abortion and the fundamental question of when does life begin. Seems to me this little person is alive. We were all there once.

3 month old fetus:


http://www.dushkin.com/connectext/psy/ch03/fetus.mhtml

4. Week 9 - Basic brain structure of the fetus is complete. Again, the ability to think and reason is one of the things that sets us apart from other species. I realize this says “basic brain structure”, but it also means the potential is there.

5. 3 months - capable of hearing. I think that some sounds can be heard through the womb and this is important to recognise. Maybe some sounds will agitate the baby.









http://www.laserprofessor.com/pimages/Mo3baby.jpg


Now we can share music. Time to put on the headphones.











http://www.sciam.com/media/inline/FBB1ABAE-E7F2-99DF-3C2FEE4066F9308B_1.gif

Also sex organs can be detected. This is significant because we can pick a name and paint the walls of the nursery, if the sonographer is competent and the baby is cooperative.


6. 4 months: babies sucking thumbs. This is important because the fetus can self-comfort. I wonder if this is an accident that the thumb touched the mouth and the instinct to suckle drew the thumb in or it becomes a conscious action.

7. 5 months: baby can kick hard enough for mom to feel. The pic below is actually a five month fetus sucking his thumb. An amazing photo. I think that feeling the baby moving inside your own womb is an amazing experience and significant because you become aware of this lively, purposeful baby. Each one of my kids had different types of movements which was consistent with their personalities.


5 month old fetus:

http://survivors.la/images/19-weeks.jpg


8. 7 months – taste buds have developed. I personally like that my taste buds work and think this is a very important and vital function.



Yummmm . . .


http://livingwithcfs.files.wordpress.com/2007/10/chocolate.jpg

9. 8 months – most organs are fully developed except for the lungs. This means that the baby is almost ready. The last month will be the longest.



Eight month fetus:


http://www.babycenter.com/fetal-development-images-36-weeks
10. 9 months – now fully developed and can survive outside of mom’s body. The baby will drop down and if normally positioned, the head will rest on the cervix, ready for delivery. The most anticipated event in the world! All systems are go and hopefully all will go well.

The fruit of our labor:

http://www.linnealenkus.com/image/newbornLLS01.jpg

Unit IV Compendium

Compendium Unit IV
Chapters 16-17

16.1 Human Life Cycle

Human reproduction is possible when a person completes puberty. In girls, that is reached at age 11-13 and boys at 14-16 years of age. To follow are the different functions of organs for each sex:
Male: Produce sperm Female: Produce eggs
Nurture sperm Transport egg to uterus
Penis delivers sperm into vagina Vagina receives sperm and provides conduit to egg
Testes produce sex hormones Uterus provides locale for fetal development
Vagina is pathway for delivery
Ovaries produce sex hormones
There are two types of cell division: mitosis and meiosis. Mitosis is duplication from one cell dividing producing two cells each containing all 46 chromosomes. Meiosis occurs only in the testes and ovaries of the reproductive organs. Each sperm and egg cell produces contain only 23 chromosomes so that when united, the zygote will have all 46 chromosomes.

16.2 Male Reproductive System

The testes (gonads) are the primary sex organs of the male reproductive system. The testes produce sperm and sex hormones. The scrotum will regulate the temperature of the testes by raising or lowering the testes from the body. Too warm and the sperm will not be viable. The sperm than mature and are stored in the epididymides. The sperm then leave the epididymides and can be stored in the vas deferens or transported onward. After entering the ejaculatoroy duct, nutrients and semen are contributed by the seminal vesicles, prostate gland, and bulbourethral glands.

Male reproductive anatomy:

www.drstandley.com/bodysystems_malerepro.shtml

I will not be commenting on the act of intercourse, since this is a public internet site. There may be greater than 400 million sperm in 3.5 mL of semen.
The Seminiferous Tubules are the locations of sperm production. It takes 74 days for sperm to develop. Mature sperm have 3 parts, head, middle piece, and tail. The head is covered by acrosome, which contains an enzyme to penetrate the egg. The middle piece has mitochondria which provides energy for movement. The tail flagellates to propel the sperm. The interstitial cells in the testes produce the sex hormones. The hypothalamus in the brain produces gonadotropin-releasing hormone (GnRH) that stimulates the anterior pituitary to release gonadotropic hormones, both follicle stimulating (stimulates sperm production) and luteinizing hormones (stimulates testosterone production). Testosterone maintains normal development and functioning of the sexual organs. It also gives males some of their male traits, such as greater muscle mass, lower voices, adam’s apple, broader shoulders and greater height.

16.3 Female Reproductive System

Ovaries are the female gonads. The produce eggs, estrogen and progesterone. The ovaries are located at one end of the fallopian tubes. They are not connected. The fallopian tubes have fimbriae (projections that sweep over the ovaries) and cilia which “brush” the eggs after they emerge from the ovaries in the direction of the uterus.

encarta.msn.com/media_461545224_761560628_-1_...

An egg is only viable for 6-24 hours until fertilization occurs. Fertilization usually occurs in the fallopian tube. The developing fetus (zygote, at this stage) arrives and implantation occurs in the thickened uterine lining. The uterus prior to emplantation is approx. 5 cm wide and can stretch to over 30cm wide when pregnant. The lining of the uterus is called the endometrium comprised of two layers, the basal laer and the functional layer. The cervix is at the base of the uterus and leads to the vaginal canal.

www.choicetolivewith.com/.../implantation.jpg

The external genitalia is collectively called vulva. The outermost folds are called labia majora. Moving medially, the next folds are called labia minora. Ventrally, they join to form a foreskin for the clitoris, this is the organ of arousal in a woman. Just dorsal to that is the urethra and then the vagina.

16.4 Female Hormone Levels

Hormones cycle an average of every 28 days. This is ovary-driven. An ovary initially contains as many as 2 million follicles and only about 400 will ever mature to produce an egg. Generally speaking, only one egg is produced every month.

Genetic spicing gone wrong. The chicken must have died,

there's not a full dozen.

www.worth1000.com/entries/53000/53426QwYU_w.jpg

Back to the basics . . .

The human cycle is depicted in the picture below:
http://www.anselm.edu/homepage/jpitocch/genbio/repronot.html

After the oocyte is released, the follicle develops into a corpus luteum. This produces progesterone and a little estrogen. As in men, the hypothalamus controls sexual function by releasing gonadotropin-releasing hormone. This stimulate the pituitary to produce FSHand LH, which control the ovarian cycle. During the first half of the cycle, the FSH stimulates the follicle in the ovary to produce estrogen which cignals the hypothalamus to secrete GnRH which in turn leads to a surge of LH production by the anterior pituitary and ovulation. The LH matures the corpus luteum and progesterone is secreted. Estrogen is responsible for our feminine traits. In encourages fatty accumulation under the skin, lending a softer appearance. The ovarian cycle will cease at around 50 years of age. The ovaries fail to respond to GhRH and no longer secrete estrogen and progesterone.
The uterine cycle is the response to the fluctuating hormones. The lining of the uterus will thicken to accommodate a possible developing embryo and this will slough off if an egg is not fertilized that month resulting in a menstrual period.
Pregnancy: Once a sperm has fertilized an egg, it becomes a zygote. This implants in the lining of the uterus. At the place where the molecules of fetal blood and maternal blood are exchanged, a placenta will develop. Progesterone production increases and will stop follicles from producing more eggs during the pregnancy. The placenta will begin to produce progesterone and estrogen and the corpus luteum will regress.

16.5 Control of Reproduction

There are multiple methods available to prevent pregnancy from occurring. They are listed below and these rates are applicable only when the methods are used correctly:

http://www.fda.gov/fdac/features/1997/babytabl.html

Abstinence is the only guaranteed method of birth control and it also has the advantage of no STD transmission. Morning after pills are administered 1-7 days after intercourse has occurred. It upsets the progesterone cycle preventing the implantation of the embryo. RU-486 is a different type of morning-after pill that causes the endometrium to slough, of course the embryo goes with it.
Infertility is deemed such after one year of regularly attempted impregnation. Low sperm count is one cause of infertility. Too much sitting, smoking or drinking alcohol can cause this. Overweight women may fail to ovulate. Blocked oviducts from pelvic inflammatory disease and endometriosis can prevent the journey of the egg to the uterus also causing infertility.
There are technologies available to help infertile couples have children. Artificial insemination is when the sperm is placed in the vagina by a physician. This is helpful when the male has a low sperm count. Sometimes fertility drugs are given to the woman to produce one or more eggs and the sperm is placed directly into the uterus. In Vitro Fertilization, conception is attained in the lab. Then the embryos are transplanted in the uterus of the woman. Sometimes, other women are contracted to give birth. The egg and sperm can be from the desiring parents. Scientists can also inject a single sperm into and egg and then transplant it into the mom’s uterus.

16.6 Sexually Transmitted Diseases

Viral Sexually Transmitted Diseases
HIV – precursor to AIDS. First stage of infection can be asymptomatic, but highly contagious. This may develop into AIDS when the helper T cell count falls dangerously low and the host cannot fight infections. AIDS patients usually die from opportunistic infections that would normally be stopped by a healthy immune system.
Genital Warts – caused by the human papillomaviruses. The carriers may not have warts and may have less noticeable flat lesions. A baby can pick up this virus as it passes through the birth canal. Vaccinations are available for some the common strains of this virus. 90% of all cancers of the cervix are thought to be caused by this virus.
Genital Herpes – Herpes simplex type 2. This is presented with blisters, tingling or itching sensations. Some events may be accompanied with fever, pain with urination, or swollen lymph nodes and the person is very contagious at this time. Newborns may pick this up through the birth canal.
Several types of hepatitis are acquired through sexual transmission. This generally causes liver damage.

Bacterial Sexually Transmitted Diseases

These are curable with antibiotics. Some resistant strains may require taking stronger drugs for a longer amount of time.
Chlamydia – mild or asymptomatic in women. If undiagnosed, can spread from the cervix to the fallopian tubes causing pelvic inflammatory disease, a very painful condition which may result in infertility.
Gonorrhea – can lead to pelvic inflammatory disease in both males and females. Gonorrhea will infect whatever part was exposed to the virus and can be spread to internal parts, causing heart damage or arthritis. Because of increased resistance to antibiotic therapy, 40% of all strains don’t respond to therapy.
Syphilis – also potentially deadly, begins as a small ulcer (chancre) that resolves on its own. Then the infected person will develop a rash that does no itch and is seen on palms and soles of feet. This, too, will resolve. The last stage may affect the cardiovascular system by causing aneurysms and ulcers on the skin or internal organs. Early diagnosis and treatment is vital for successful treatment.
Other Common Infections
Bacterial vaginosis is asymptomatic and can be due to nonsexual reasons, or may have been passed on from infected males. Candida albicans (non-sexual) and Trichomonas (sexual) are vaginal infections treated with oral or topical medications.

Chapter 17: Development and Aging

17.1 Fertilization

The flagellum moves the sperm toward the egg. The arcosome on the head contains enzymes that will penetrate the zona pellucid.

http://www.wccusd.k12.ca.us/gompers/HealthScience/BodySystems/FemaleReproductiveSystem.html

As soon as the head touches the plasma membrane, it will depolarize prohibiting the penetration of more sperm. When a sperm enters an egg to form a zygote, fertilization occurs.


17.2 Pre-Embryonic and Embryonic Development

Immediately after fertilization, the cells begin to divide within the zygote but it doesn’t increase in size. Then the daughter cells begin to increase in size. At morphogenesis, the cells migrate and begin to form the shape of the embryo. Differentiation is when the cells begin to function according to their structure. The nervous system is the first to appear.

The structures that support the embryo are pictured below.
Chorion – becomes the fetus’ half of the placenta.
Allantois – extends away from the embryo, collects urine before bladder develops. The blood vessels will become the umbilical blood vessels.
Yolk Sac – first embryonic membrane to appear. It contains a small amount of yolk. The placenta will soon take over.
Amnion – contains fluid which will protect the baby.

http://www.mansfield.ohio-state.edu/~sabedon/campbl34_files/image037.gif

From a zygot, to a morula, to a blastocyst, this will separate into the embryo inside and the outer layer called a chorion. Embryonic development begins the second week. The chorion will secret enzymes to eat away some the tissue of the endometrium and implant. It will also secrete human chorionic gonadotropin which will preserve the lining of the uterus until the pregnancy is completed. This is the start of gastrulation, forming of three primary germ layers:
Ectoderm: outer layer forming the epidermis, lining of oral cavity and nervous system
Mesoderm: middle layer forming the skeleton, muscles, dermis, CV system, urinary system,
reproductive system, outer layers of respiratory and digestive systems
Endoderm: inner layer forming the digestive tract and respiratory tract and their glands.
In the third week the nervous system and the heart begins to form. At the end of the fifth week the umbilical cord will be fully formed. Little limb buds become apparent. At the end of eight weeks, the nervous system has developed enough to permit a startled response. The embryo is about 1.5 inches long and all organ systems are present.

In the picture, ten models, approximately life-sized, represent eight weeks of embryonic development, at the end of which main organ systems, limbs and features have taken shape.
http://www.doc.ic.ac.uk/~gzy/heart/heart/embryo.htm

17.3 Fetal Development

At the third month the uterus is the size of a grapefruit and gender can be detected by ultrasound.
By four months, the skeleton is visible and hair is growing. At five months, a coating is developing on the baby and the heartbeat can be heard. By the seventh month, the testes descend in to the scrotom and the eyes are open. At eight months, the baby begins to develop that cute fat and is ready for birth at nine months.

Cute baby fat . . .

http://www.humorupload.com/files/F4A589dzy.jpg

During pregnancy, the placenta will become the source of progesterone and estrogen to discourage follicle stimulation and to maintain the endometrium.

The path of fetal circulation

http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/cardiac/fetlcirc.html

Blood is received from the placenta, goes through the liver and is received in the right atrium. Some of it is shunted through the foramen ovale directly to the left atrium, then the left ventricle. Some of the blood in the right atrium will be pumped into the right ventricle where it will be sent through the pulmonary trunk and arterial duct to the aorta as well. The ventricle pumps the blood to the aorta and is then sent to the head and body and returns to the right atrium. Desaturated blood is returned to the placenta via the umbilical arteries. At birth the foramen ovale and arterial ducts will usually close in order to route the blood through the lungs when they start working.
At six weeks, the genitals are indifferent – no specific gender. A gene (SRY) will signal for testes to develop and the testes will produce testosterone. Without SRY, ovaries will develop. Genitals will develop into distinct gender at around 14 weeks.
People with the XY chromosome are males and XX are females. There are a few abnormal developments that make the determination ambiguous. The androgen insensitivity syndrome is when the membrane receptors for testosterone are ineffective. The person will develop as a female and it is not discovered until she fails to menstruate.

17.4 Pregnancy and Birth

Needs no introduction . . .

randobs.blogspot.com/2008/01/pregnant-wife.html

Initially, one the the first symptoms of becoming pregnant is nausea, vomiting or loss of appetite. She may also become tired. This usually subsides after the first trimester. Energy and stamina are reported often throughout normal, progressing pregnancies. She will gain weight from the enlarging uterus and baby developing inside, her breasts are also enlarging, and her own increase in body fluid (40% increase in blood volume) and fat stores. Increased Progesterone levels will relax smooth muscles also causing perhaps, heartburn and constipation. The tidal volume of her lungs will increase 40% and carbon dioxide levels will fall 20%. Pressure from the uterus on the bladder can cause frequency and incontinence. Pressure on the vena cava will decrease venous return and may cause varicose veins and swollen legs.
As she approaches labor, contractions experienced throughout the pregnancy will become stronger. False labor or Braxton Hicks contractions may fool her into believing it is time for delivery. True labor is defined by contractions every 15-20 minutes lasting at least 40 seconds or longer.
The stretching cervix stimulates the release of oxytocin from the pituitary gland. This stimulates the uterine muscles. During Stage 1 of labor the uterus will push the baby harder against the cervix. When the cervix is completely dilated, Stage 1 is over. Stage 2 is the birth of the baby. Contractions occur more frequently to push the baby through the birth canal. During a normal presentation, the head appears first. Complications may occur if a different part presents. Stage 3 is the delivery of the placenta. The uterus continues to contract which shrinks the uterus and displaces the placenta.

Definitely worth the effort . . .

http://amazinasian.com/weblog/pics/59425792105_0_ALBsmall.jpg

17.5 Development after Birth

Gerontology is the study of aging. It has been the pursuit of many to find the fountain of youth. Research as to why we age has produced a mitochondrial hypothesis – when mitochondria produce energy, they produce free radicals (extra electrons). These attach to other molecules which become disabled and are destroyed. A restricted food intake shuts down the genes the turn on the activity of the mitochondria.
Many hormones also diminish or receptors become resistant. The thymus gland decreases in size and our immune response diminishes. Cancers increase in incidence as we age. Collagen stiffens and effect the elasticity of tendons and ligaments and skin (becomes thinner and less elastic). Hair follicles lessen in number and a decrease in melanocytes causes what hair is left to turn gray and skin to pale. Cardiovascular problems are associated with loss of muscle and hardening and narrowing of the arteries. Blood flow is reduced to all systems of the body and everything functions subpar. Medication must be closely monitored because the filtering of the kidneys and liver are diminished and unsafe levels can occur when elimination is compromised. The digestive tract also slows causing hearburn and slow elimination. Good news is that few neural cells of the cerebral cortex are lost during the aging process. It takes longer for a senior to learn new facts, but one can if given the time to do so. Diminished hearing and vision, glaucoma, loss of muscle mass, inability to hold urine, bone density decline, arthritis and weight gain are all problems shared by the elderly. Why are these the “Golden Years?”
Women enter menopause around 50 years of age and men enter andropause somewhat later between 50-90. Both signify a decrease of the sex hormone and diminished libido.
Many of the problems associated with aging can be avoided with good health habits developed earlier in life.

http://www.fammed.washington.edu/network/sfm/gerihands.jpg

Unit III: Self and Unit Evaluation

REGARDING YOUR OWN PERFORMANCE
I posted this before finding the other site . . . so posted there, too.
1. What were the three aspects of the assignments I've submitted that I am most proud of?
Again, completing the unit.
Developing an understanding of the topics.
Not being as overwhelmed, (still many hours spent) and finding it more enjoyable.
2. What two aspects of my submitted assignments do I believe could have used some improvement?
You'll have to let me know . . .
3. What do I believe my overall grade should be for this unit?
Hoping again for another A!
4. How could I perform better in the next unit?
Still struggling with time management.


REGARDING THE UNIT (adapted from Stephen Brookfield, University of St. Thomas "Critical Incident Questionnaire")
At what moment during this unit did you feel most engaged with the course?
I have to admit that building the model definately pulled me into the
whole nerve/muscle dynamic.

At what moment unit did you feel most distanced from the course?
Again, the compendiums.

What action that anyone (teacher or student) took during this unit that find most affirming and helpful?
Had no contact with either.

What action that anyone (teacher or student) took during this unit did you find most puzzling or confusing?
Had no contact with either.
What about this unit surprised you the most? (This could be something about your own reactions to the course, something that someone did, or anything else that occurs to you.)
I am beginning to enjoy acquiring the knowledge. Even though the compendiums are the worse part of this course, I have to admit they do help the information to stick. Building the limb forced my lazy mind to grasp the dynamics well enough to model and explain it. So I have to say thank you for arranging the class as you have, Mr. Frolich.

Compendium III

Chapter 11: Skeletal System

http://www.contmediausa.com/shop/app/products/Human3D/Images/BS000A.jpg

11.1 Overview of a Skeletal System

The skeleton supports the body, protects organs and soft parts, produces blood cells, stores minerals and fat, is utilized by muscles to produce movement.
A long bone has a shaft (diaphysis) containing a medullary cavity. Ths is lined with yellow bone marrow that stores fat. The rounded ends of the long bone are called epiphyses. These have spongy bone matter containing red bone marrow where the blood cells are made.. The outer ends of the epiphyses are covered with articular cartilage where the joints articulate.

Example of Long Bone

http://www.web-books.com/eLibrary/Medicine/Physiology/Skeletal/long_bone.jpg

Except for these areas, the rest of the bone is covered with a periosteum which contains blood and lymphatic vessels, and nerves. These penetrate the bone for exchange of nutrients/wastes. Compact bone is comprised of bone cells (osteocytes) arranged around the central canals which form the walls of the diaphysis. Spongy bone has a sponge-like appearance (d-uh). Thin plates (trabeculae) are separated by uneven spaces. These are also very strong and provide ample support. These are filled with red bone marrow. Cartilage has a flexible gel-like matrix and contains no nerves or blood vessels. Hyaline cartilage forms articular cartilage. Fibrocartilage is stronger and provides support in the vertebrae and knees. Elastic cartilage is as it sounds, more flexible and comprises the ear flaps and epiglottis. Ligaments and tendons are made of fibrous connective tissue. Ligaments connect bone to bone and tendons connect muscles to bones at joints.

11.2 Bone Growth, Remodeling, and Repair

Bones start to form in the fetus at six weeks when it is about ½ inch long. Bones will continue to grow or respond to stresses throughout a lifetime. Remodeling is a reaction to stresses. Bone repair is healing after a fracture.
These cells are involved in those processes:
Osteoblasts - form bone. Build the matrix and facilitate the deposit of minerals.
Osteocytes – when osteoblasts become trapped within the bone matrix, they become osteocytes which maintain the structure of the bone.
Osteoclasts - break down any extra bone framework that the osteoblasts make and help to deposit calcium and phosphate in the blood.
Ossification is the formation of bone. This occurs two ways:
Flat bones are formed from intramembranous ossification between sheets of fibous connective tissue. Long bones (most of the bones of the human skeleton) are formed by endochondral ossification. Cartilage is replaced by bone. This will continue as long as the growth plate is present. This activity will cease in women around age 18 and in men around 25 years. The diameter of a bone will grow as the bone lengthens.
Vitamin D encourages absorption of calcium in the digestive tract. Growth hormone when supported by the thyroid hormone stimulates bone growth.
Bone remodeling, or renewal, recycles as much as 18% of bone matter. This allows the body to regulate how much calcium in concentrated in our blood. Parathyroid hormone increases calcium concentrations in the blood and calcitonin has the opposite effect. Estrogen can increase osteoblasts and that is why women, whose estrogen levels are diminishing in menopause, suffer bone loss. Stress that encourages bone growth is not a bad thing, walking, strength training and jogging all encourage stronger bone growth.

Image below:
1. Hematoma forms at break 2. Fibrocartilaginous callus will fill the space 3. Bony callus formed by osteoblasts. 4. Osteoblasts build new compact bone and osteoclasts create new medullary cavity.

http://www.apatech.com/storage/images/bone2.jpg

11.3 Bones of the Axial Skeleton

The skull:
The Skull is formed by the cranium and bones of the face. These bones join together at around age 16 months. The cranium contains the sinuses which adds resonance to our voices and its airy consistency reduces the weight of the skull. The bones of the skull have the same names of the lobes of the brain. The Sphenoid bone is the keystone for all the other bones of the cranium. It extends across the floor of the cranium and up the sides.

Cranium


www.mc.maricopa.edu/dept/d10/asb/anthro2003/origins/webanatomy/cranium.html

Axial Skeleton

http://staff.tuhsd.k12.az.us/gfoster/standard/axial.gif

The Facial Bones: Pictured below:

www.mc.maricopa.edu/dept/d10/asb/anthro2003/origins/webanatomy/cranium.html

The mandible is the jaw – the only part of the skull that moves.
The Hyoid Bone: The hyoid is the only bone in the body that does not interact with another bone. It is attached to the temporal bones and the larynx by ligaments and membranes. A fractured hyoid is a warning that someone
may have strangled this person.

The Vertebral Column:

http://www.spineuniverse.com/displaygraphic.php/171/spine3-BB.jpg

Consists of 33 vertebrae. The normal curvature of the spinal column gives it strength. Abnormal curvatures sometimes occur. Scoliosis is a sideways curvature and Lordosis is a “swayback” or anterior curvature. There are disks between the vertebrae that absorb shock experienced from various movements. If these are compressed or bulging, they can press on the spinal nerves.
The Rib Cage: protects the heart and lungs and is flexible to allow for breathing.
The Sternum: also protects the heart and lungs.

http://academic.wsc.edu/faculty/jatodd1/351/thoarcic_cage.jpg

11.4 Bones of the Appendicular Skeleton

http://staff.tuhsd.k12.az.us/gfoster/standard/append.gif

Arms and shoulders - part of the appendicular skeleton


http://en.wikipedia.org/wiki/Image:Human_arm_bones_diagram.svg

Legs, hips and pelvis - lower part of appendicular skeleton

http://www.dmacc.edu/instructors/rbwollaston/Skeletal_System/pelvic_girdle.gif

11.5 Articulations

The joints where bones articulate. Fibrous joints don’t move. Cartilaginous joints are only slightly flexible.
Synovial (fluid-filled sacs) joints have different types of movements.

Samples of joints:

http://www.shelfieldpeonline.co.uk/assets/images/types_20of_20synovial_20joints.jpg
Chapter 12: Muscular System

12.1 Overview of muscular System

Types:
Smooth: is involuntary and internal, nonstriated, uninucleated fibers
Cardiac: is involuntary, located in heart, striated and branched
Skeletal: is voluntary, striated, tubular and is usually attached to a skeleton
http://www.nsbri.org/HumanPhysSpace/focus5/f5-190.jpg

Skeletal muscles support the body, move our bones, produce heat, assists with venous and lymph return, and protects organs. Muscles work in pairs, one contracts to move the appendage in one direction and its synergist or antagonist will move the appendage back to the original position.

Below, is someone who does this a lot.

http://www.artlex.com/ArtLex/e/images/ecorche_contemp.chart.lg.jpg

12.2 Skeletal Muscle Fiber Contraction

Muscle fibers are cells that have similar cellular componants to other cells, but they have been given specific names. The plasma membrane is sarcolemma, cytoplasm is sarcoplasm, endoplasmic reticulum is sarcoplasmic reticulum.

Anatomy of muscle and how it is attached to the bone

http://www.sci.sdsu.edu/class/bio590/pictures/lect1/structureofskelmus1.jpeg

More anatomy of muscle:

http://www.etsu.edu/cpah/hsci/forsman/Histology%20of%20musclefor%20web_files/image009.jpg

The sarcopasmic reticulum contains myofibrils (contractile portions) and other organelles are located between the myofibrils. Glycogen is stored in the sarcoplasm as well as myoglobin which stores oxygen.
Sarcomeres cause striations in skeletal muscle and contain two types of protein myofilaments, thicker filaments are called myosin and the thin ones are called actin. During contraction calcium is released from the sarcoplasmic reticulum. In response, the actin slides past the myosin towards each other which shortens the muscle. This is called the sliding filament model.

Actin and Myosin filaments

http://www.exrx.net/ExInfo/Muscle.html

Motor neurons stimulate muscles at the synaptic cleft . Neurotransmitters cross the cleft binding to receptors in the sarcolemma. The sarcolemma signals impulses over the sarcolemma and down T Tubules to the Sarcoplasmic reticulum causing contraction.

12.3 Whole Muscle Contraction

Each axon from one nerve can stimulate a number of muscle fibers. This entire group is called a motor unit. In the leg, one axon can stimulate 1000 muscle fibers, by contrast the ocular muscle group may only stimulate 23 muscle units per axon. A twitch is a short burst and a rapid series of stimuli can result in increased muscle contraction – maximum is called tetanus. When fatigue occurs, the muscle will relax even though stimuli has not.
Muscles use 4 different types of fuel sources:
Muscle triglycerides, plasma fatty acids, blood glucose, and muscle glycogen.
The creatine phosphate pathway is the quickest way to for muscles to obtain energy. This method is good for the beginning of low level exertion or 5 seconds of short-burst, high energy exertion.
The creatine is created while the muscle fibers are at rest in the midst of the sliding filaments. Only one reaction is needed to produce ATP. If the energy requirements are more than what’s available from the CP pathway, the body will utilize fermentation.
Fermentation is also fast-acting, but will result in the build-up of lactate. It is anaerobic. The process produces an oxygen debt which causes increased respirations after the exercise has ceased. The lactate will be broken down the CO2 and water (20%), and converted back into glucose and glycogen.
Cellular Respiration is used mostly when exercise is below the maximum one can expend. It uses fatty acids or glycogen stored in the muscles. This is the exercise most desirable for losing weight.
Our muscles have two types of fibers:
Fast Twitch: these are anaerobic and have more power, but fatigues easily.
Slow Twitch: are aerobic and have more endurance, good for jogging, biking or swimming.

12.4 Muscular Disorders

Spasms are intermittent involuntary muscle contractions. These can be annoying or painful. Cramps are stronger, painful spasms. Facial tics are spasms affected our faces, therefor expressions. These are involuntary, but can be controlled with difficulty.
Strains are injuries that affect muscles or tendons, thick bands that attach muscles to bones. They occur in response to a quick tear, twist, or pull of the muscle. Strains are an acute type of injury that results from overstretching or over contraction. Pain, weakness, and muscle spasms are common symptoms experienced after a strain occurs.
Sprains are injuries that affect ligaments, thick bands of cartilage that attach bone to bone. They occur in response to a stretch or tear of a ligament. Sprains are an acute type of injury that results from trauma such as a fall or outside force that displaces the surrounding joint from its normal alignment. Sprains can range from a mild ligamentous stretch to a complete tear. Bruising, swelling, instability, and painful movement are common symptoms experienced after a sprain occurs. http://physicaltherapy.about.com/od/sportsinjuries/a/strainvssprain.htm

Tendinitis is inflammation of the tendon. Bursitis is inflammation of the bursa (sac that cushions joint movements).
Myalgia is aching muscles. Fibromyalgia – a controversial chronic painful condition involving muscles. Muscular Dystrophy is an inherited condition in which there is progressive weakening of the muscles. Myasthenia Gravis is an autoimmune disease that destroys acetylcholine receptors. This is more pronounced in the head, neck, and extremities. Amyotrophic Lateral Sclerosis is also known as Lou Gehrig’s disease. Gradual loss of muscle use results in inability to chew or swallow resulting in death.

Body dysmorphic disorder – being excessively concerned and preoccupied with an imagined or minor defect in their appearance
http://farm1.static.flickr.com/144/367772579_ab90abdfd2.jpg

12.5 Homeostasis

Both muscular and skeletal systems work to maintain homeostasis.
Movement: Muscles move and are supported by skeleton
Protection: Both protect body parts
Bones are influenced by hormones to store and release calcium. Muscles need calcium for contractions.
Bones produce blood cells. Red blood cells carry oxygen needed to produce ATP by aerobic cellular respiration. White cells fight infection.
Muscles help regulate body temperature. Contracting muscles produce heat. That is why when you’re very cold, you shiver.

skyview.billings.k12.mt.us/.../shivering.gif

Exercise, Is the Concept Working?




http://supplementalscience.files.wordpress.com/2007/05/exercise.gif

I think we have intellectual awareness of the need to exercise. I’m certain we’ve all heard the call, seen the dismal statistics of obese-related health problems . . . and their cost. The estimated total cost of obesity in the United States in 2000 was about $117 billion, that was eight years ago.

I would say we all know we should be doing it. So why aren’t we? Here’s some sobering stats:

“Since the mid-seventies, the prevalence of overweight and obesity has increased sharply for both adults and children. Data from two NHANES surveys show that among adults aged 20–74 years the prevalence of obesity increased from 15.0% (in the 1976–1980 survey) to 32.9% (in the 2003–2004 survey). The two surveys also show increases in overweight among children and teens. For children aged 2–5 years, the prevalence of overweight increased from 5.0% to 13.9%; for those aged 6–11 years, prevalence increased from 6.5% to 18.8%; and for those aged 12–19 years, prevalence increased from 5.0% to 17.4%.”
“Despite the proven benefits of physical activity, more than 50% of U.S. adults do not get enough physical activity to provide health benefits; 24% are not active at all in their leisure time. Activity decreases with age, and sufficient activity is less common among women than men and among those with lower
incomes and less education. Insufficient physical activity is not
limited to adults. About two-thirds of young people in grades 9–12 are not engaged in recommended levels of physical activity. Daily participation in high school physical education classes dropped from 42% in 1991 to 33% in 2005.” http://www.cdc.gov/nccdphp/publications/aag/dnpa.htm

http://www.aafp.org/fpr/20001100/8_f1.jpg

Below is a map showing the growing rate of obesity in the USA over the last 15 years.

http://www.cdc.gov/nccdphp/publications/aag/dnpa.htm

I know the things in my world that make exercising difficult. It’s inconvenient, uncomfortable, sweaty, boring, and painful. Now, I realize we don’t have to lift weights to be healthy, and I don’t. There are far less demanding ways to lead an active life without becoming an athlete. The American Diabetes Association has several wonderful suggestions for gently incorporating movement into your day. Even just cleaning your house is a wonderful low-level activity. Getting up to change the channels and mowing the lawn are also suggested. Here’s a good one, playing with your kids.
This brings me to the “easy way”. We are creatures of comfort and it is hard to motivate ourselves to work harder than we have to. Most of our economy is based on convenience items: remotes for our TV’s, automobiles for everyone of age, elevators, even men in golf carts to drive you to the big building so you don’t have to walk too far. I’ve seen easy chairs with cup holders and meal trays built right in. Even our food is easier to prepare. Scissors are now a staple in my kitchen so I can cut those bags of frozen dinners open – seemed homemade since I dirtied a pan.
There are so many benefits to exercising regularly:
Physical activity improves quality of life.
Physical activity extends longevity, protects against the development of
CHD, stroke, hypertension, obesity, non-insulin-dependent diabetes
mellitus, osteoporosis, colon cancer, and depression.
Physical activity helps maintain full functioning and independence among
the elderly.
Relationships between physical activity and improved health include:
A reduced oxygen demand at any given level of physical activity.
A reduced tendency for blood to form clots where arteries have narrowed.
An increased elasticity in the arteries.
Changes in the brain and brain chemistry that may improve mood and
cognitive functioning.
More than 60% of US adults do not engage in the recommended amount
of activity.
Approximately 25% of US adults are not active at all.
A 1993 study concerning causes of death in the US: #1 Tobacco, #2 Lack of
exercise/poor diet, #3 Alcohol.
Chronic disease costs the US $655 Billion in healthcare costs.
In this year, 1.5 million people will have a heart attack in the US and
500,000 will die. http://www2.gsu.edu/~wwwfit/physicalactivity.html

Gamers now have video games that involve whole body movement, Wii is one. It’s quite popular at the nursing home I work at. With that game, people are moving as though they are playing a sport while holding a little box. This appears as a sport on the TV set and their movements are mimicked by the cartoon character that is playing them. Well, this is a start.
How do we get motivated? Peer pressure might help. Through government programs, involved citizens, and media coverage, many people might think again about getting off their you-know-whats. Scotland has many successful programs for activities. The constant for all of the programs is hiring enthusiastic, dedicated individuals to run them. Enthusiasm is contagious. In smaller communities, scheduled walking outings are offered a few times a week and locals need only to find the one that fits their schedule.

Encouragement and availability are key factors to participation. Of course, our food chain needs re-vamping as well, but that was our essay in the last unit.

Unit III Lab Project: Build a Movable Limb

Build a Limb Project

For this project, I will demonstrate how muscles and bones work together to produce movement. For this demo, I will model the arm.

Some raw materials:

The backscratch gave his life . . .

The operation: in progress.

After careful planning and assembling, the patient experiences - movement!

An explanation:

The motor neuron (white balloon in the hand of the operator/surgeon) signals the bicep. You can see the muscle responding to the stimuli by contracting. As it contracts, the diameter of the muscle increases, as mass remains the same (is it becomes shorter, it must get larger somewhere else). If this were more anatomically correct, the muscle would also be harder during contraction. The shortening of the muscle and pulling draws the forearm upwards, pivoting on the elbow joint.

Some stills . . .

Close up of motor unit

It's hard to see the action potential coarsing along the axon, there is a slight purple color to indicate that between the schwann cells. This potential will result in a release of ACh from the axon terminals. The neurotransmitter will then bind to the receptors in the sarcolemma. Then calcium will be released from the sarcoplasmic reticulum and will bind to troponin on the actin filament.

This deposition of calcium causes the troponin to move and expose the binding sites for the myosin.

Relaxed state of sarcomere

The myosin has heads that will extend to the binding sites on the actin forming a cross-bridge and will pull the actin closer together. ADP is utilized for this action and ATP is needed for the heads to release from the binding sites.

Contracted state of sarcomere

All of these actions happen at an amazing rate. Just think about how often you move without even thinking about it. Knowing the mechanics and chemical reactions needed to move one fibril makes my head spin. Even as I'm typing this report, I am amazed (can't think of a better word) by the effortless motions of my fingers in leiu of the magnitude of activities that are needed to accomplish it.